Joint project
GANI_MED Greifswald Approach to Individualized Medicine (Projektverbund)
Involved Persons and Affiliations
Involved Institutions
Further information
URL/Weblink: http://www.medizin.uni-greifswald.de/GANI_MED/
Übersicht
Projektdaten
| Acronym | |
| Project period | 01.10.2009 - 30.09.2014 |
| Project type | Joint project |
| Project funding | externally funded |
| Sponsor | Bundesministerium für Bildung und Forschung (BMBF), Landesregierung M-V, Bundesministerium für Bildung und Forschung (BMBF) |
| Additionally financed from own funds | no |
Publications
Towards a unified concept of individualized medicine
Prevalence, incidence and risk factors of testosterone deficiency in a population-based cohort of men: results from the study of health in Pomerania.
ß-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein ß-3 subunit variant.
A genome-wide association study of metabolic traits in human urine.
Self-perceived quality of life predicts mortality risk better than a multi-biomarker panel, but the combination of both does best
Serum thyrotropin levels and blood pressure response to exercise in a population-based study.
Low serum testosterone is associated with increased mortality in men with stage 3 or greater nephropathy
Association between glycosylated haemoglobin A(1c) and endothelial function in an adult non-diabetic population.
The association of serum prolactin concentration with inflammatory biomarkers - cross-sectional findings from the population-based Study of Health in Pomerania.
The androgen receptor CAG repeat polymorphism as a risk factor of low serum testosterone and its cardiometabolic effects in men.
Comparing different scientific approaches to personalized medicine: research ethics and privacy protection.
Genetic determinants of serum testosterone concentrations in men.
Improved prediction of all-cause mortality by a combination of serum total testosterone and insulin-like growth factor I in adult men.
Age- and sex-specific reference limits for creatinine, cystatin C and the estimated glomerular filtration rate.
Plasma aldosterone levels and aldosterone-to-renin ratios are associated with endothelial dysfunction in young to middle-aged subjects
Age-Specific Reference Ranges for Serum Testosterone and Androstenedione Concentrations in Women Measured by Liquid Chromatography-Tandem Mass Spectrometry.
Prospective Inverse Associations of Sex Hormone Concentrations in Men with Biomarkers of Inflammation and Oxidative Stress.
Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms
Prevalence of Primary Aldosteronism in Patient's Cohorts and in Population-based Studies - A Review of the Current Literature.
Can the Hazard Assessment and Critical Control Points (HACCP) system be used to design process-based hygiene concepts?
Association of IGF-I and the IGF-I/IGFBP-3 Ratio with Plasma Aldosterone Levels in the General Population.
Diving Through the "-Omics": The Case for Deep Phenotyping and Systems Epidemiology.
Schwerwiegende Arzneimittelnebenwirkungen von Phenprocoumon: stationäre Kosten der gastrointestinalen Blutungen und Einsparungspotentiale
Zwischen Vertrauen und Kontrolle. Management interdisziplinärer Forschungsverbünde - eine exemplarische Analyse
Zielfunktionen und Allokationsentscheidungen im Krankenhaus
Screening for Primary Aldosteronism in Hypertensive Subjects - Results From Two German Epidemiological Studies.
A network-based approach to visualize prevalence and progression of metabolic syndrome components.
Compartment-Specific Gene Regulation of the CAR Inducer Efavirenz In Vivo.
The role of sex hormone-binding globulin and testosterone in the risk of incident metabolic syndrome.
Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function
Gesundheitsökonomische Forschung im Kontext Individualisierter Medizin, Forschungsethische und datenschutzrechtliche Aspekte am Beispiel des GANI_MED-Projekts
Mobile Erfassung personenbezogener medizinischer Daten in der klinischen Routine: Datenquelle für epidemiologische Studien
Was ist Individualisierte Medizin? Zur terminologischen Justierung eines schillernden Begriffs
Tagungsbericht: Zufallsbefunde als Problem medizinischer Diagnostik und Forschung, Rehburg-Loccum, 2.–3. Dezember 2011
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove.
Recent approaches to the prioritization of candidate disease genes.
Novel search method for the discovery of functional relationships
Mining GO annotations for improving annotation consistency.
Topological analysis and interactive visualization of biological networks and protein structures.
Genome-wide meta-analysis of common variant differences between men and women.
Positive association of serum prolactin concentrations with all-cause and cardiovascular mortality.
Serum prolactin concentrations as risk factor of metabolic syndrome or type 2 diabetes?
Reference intervals for serum osteocalcin concentrations in adult men and women from the study of health in Pomerania.
Personalized cardiovascular medicine: concepts and methodological considerations.
U-shaped association between central body fat and the urinary albumin-to-creatinine ratio and microalbuminuria.
NetworkPrioritizer: a versatile tool for network-based prioritization of candidate disease genes or other molecules
Der Childhood Trauma Screener (CTS) - Entwicklung und Validierung von Schwellenwerten zur Klassifikation
Hepatic Steatosis Is Associated With Aortic Valve Sclerosis in the General Population: The Study of Health in Pomerania (SHIP).
Individualized medicine, ethical, economical and historical perspectives
The Implications of the Incidentalome for Clinical Pharmacogenomics
Gesundheitliche Eigenverantwortung im Kontext Individualisierter Medizin.
Incidental Findings, Understanding of Risks by Research Subjects and Implications for Research Ethics,
Zufallsbefunde: Risikobewusstsein von Probandinnen und forschungsethische Konsequenzen
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
Comparison of genotyping using pooled DNA samples (allelotyping) and individual genotyping using the affymetrix genome-wide human SNP array 6.0.
Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics
Das Consentmanagement im Projekt GANI_MED - Umsetzung als Modul einer Forschungsplattform
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
The Lifetime Prevalence of Mental Disorders in North-Eastern Germany
A new, accurate predictive model for incident hypertension
Versatile prioritization of candidate disease genes or other molecules with NetworkPrioritizer
Genome-wide association study of chronic periodontitis in a general German population.
Circulating angiopoietin-2, its soluble receptor Tie-2, and mortality in the general population.
Correlates of adverse outcomes in abdominally obese individuals: findings from the five-year followup of the population-based study of health in Pomerania.
Relation of insulin-like growth factor-I and IGF binding protein 3 with markers of inflammation: results of a population-based study.
Do patients with type 1 and type 2 diabetes really have an impaired endothelial function? A population-based propensity score matching analysis.
Aldosterone and glomerular filtration - observations in the general population.
Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.
Deciphering the molecular signature of plaques, memory decline and neuron-loss using two mouse models for Alzheimer’s disease by deep sequencing
Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits.
Cohort profile: Greifswald approach to individualized medicine (GANI_MED).
Association of non-alcoholic fatty liver disease with chronic kidney disease: a systematic review and meta-analysis.
Blood cis-eQTL analysis fails to identify novel association signals among sub-threshold candidates from genome-wide association studies in restless legs syndrome.
Das GANI_MED-Metadatenmodell - Ein adaptives Modell zur Abdeckung breitgefächerter Anforderungen
Der praktische Einsatz des generischen Metadatenmodells G2D2
Bridging the gap: Improving Secondary Use of EHRs with i2b2
Daten aus der klinischen Routine – Was sind die Herausforderungen an eine Forschungsplattform?
Bridging the gap: Improving Secondary Use of EHRs with i2b2
Ethics Meets IT: Aspects and elements of Computer-based informed consent processing
The Meaning of “Individualized Medicine”: A Terminological Adjustment of a Perplexing Term
Individualized Medicine within the GANI_MED Project
Inventing Traditions, Raising Expectations. Recent Debates on “Personalized Medicine”
The “Epistemics” of “Personalized Medicine”. Rebranding Pharmacogenetics
Use of Biomarkers for the Prediction of Treatment Response: Immunoadsorption in Dilated Cardiomyopathy as a Clinical Example
The Role of Pharmacogenomics in Individualized Medicine
The Concept of Disease in the Era of Prediction
Informed Consent in GANI_MED — A sectional design for clinical epidemiological studies within Individualized Medicine
Handling incidental findings from imaging within IM related research—Results from an empirical-ethical Study
Individualized Medicine: From potential to macro innovation
Assessing Individualized Medicine — The example of immunoadsorption
How Individualized is Medicine Today? The case of heart failure in the G-DRG system
Translation of individualized medicine into clinics and the discourse of “hypothetical ethics”
Individualized medicine – ethical, economical and historical perspectives
Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.
Prevalence, incidence and risk factors of testosterone deficiency in a population-based cohort of men: results from the study of health in Pomerania.
ß-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein ß-3 subunit variant.
A genome-wide association study of metabolic traits in human urine.
Self-perceived quality of life predicts mortality risk better than a multi-biomarker panel, but the combination of both does best
Serum thyrotropin levels and blood pressure response to exercise in a population-based study.
Low serum testosterone is associated with increased mortality in men with stage 3 or greater nephropathy
Association between glycosylated haemoglobin A(1c) and endothelial function in an adult non-diabetic population.
The association of serum prolactin concentration with inflammatory biomarkers - cross-sectional findings from the population-based Study of Health in Pomerania.
The androgen receptor CAG repeat polymorphism as a risk factor of low serum testosterone and its cardiometabolic effects in men.
Comparing different scientific approaches to personalized medicine: research ethics and privacy protection.
Genetic determinants of serum testosterone concentrations in men.
Improved prediction of all-cause mortality by a combination of serum total testosterone and insulin-like growth factor I in adult men.
Age- and sex-specific reference limits for creatinine, cystatin C and the estimated glomerular filtration rate.
Plasma aldosterone levels and aldosterone-to-renin ratios are associated with endothelial dysfunction in young to middle-aged subjects
Age-Specific Reference Ranges for Serum Testosterone and Androstenedione Concentrations in Women Measured by Liquid Chromatography-Tandem Mass Spectrometry.
Prospective Inverse Associations of Sex Hormone Concentrations in Men with Biomarkers of Inflammation and Oxidative Stress.
Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms
Prevalence of Primary Aldosteronism in Patient's Cohorts and in Population-based Studies - A Review of the Current Literature.
Can the Hazard Assessment and Critical Control Points (HACCP) system be used to design process-based hygiene concepts?
Association of IGF-I and the IGF-I/IGFBP-3 Ratio with Plasma Aldosterone Levels in the General Population.
Diving Through the "-Omics": The Case for Deep Phenotyping and Systems Epidemiology.
Schwerwiegende Arzneimittelnebenwirkungen von Phenprocoumon: stationäre Kosten der gastrointestinalen Blutungen und Einsparungspotentiale
Zwischen Vertrauen und Kontrolle. Management interdisziplinärer Forschungsverbünde - eine exemplarische Analyse
Zielfunktionen und Allokationsentscheidungen im Krankenhaus
Screening for Primary Aldosteronism in Hypertensive Subjects - Results From Two German Epidemiological Studies.
A network-based approach to visualize prevalence and progression of metabolic syndrome components.
Compartment-Specific Gene Regulation of the CAR Inducer Efavirenz In Vivo.
The role of sex hormone-binding globulin and testosterone in the risk of incident metabolic syndrome.
Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function
Gesundheitsökonomische Forschung im Kontext Individualisierter Medizin, Forschungsethische und datenschutzrechtliche Aspekte am Beispiel des GANI_MED-Projekts
Mobile Erfassung personenbezogener medizinischer Daten in der klinischen Routine: Datenquelle für epidemiologische Studien
Was ist Individualisierte Medizin? Zur terminologischen Justierung eines schillernden Begriffs
Tagungsbericht: Zufallsbefunde als Problem medizinischer Diagnostik und Forschung, Rehburg-Loccum, 2.–3. Dezember 2011
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove.
Recent approaches to the prioritization of candidate disease genes.
Novel search method for the discovery of functional relationships
Mining GO annotations for improving annotation consistency.
Topological analysis and interactive visualization of biological networks and protein structures.
Genome-wide meta-analysis of common variant differences between men and women.
Positive association of serum prolactin concentrations with all-cause and cardiovascular mortality.
Serum prolactin concentrations as risk factor of metabolic syndrome or type 2 diabetes?
Reference intervals for serum osteocalcin concentrations in adult men and women from the study of health in Pomerania.
Personalized cardiovascular medicine: concepts and methodological considerations.
U-shaped association between central body fat and the urinary albumin-to-creatinine ratio and microalbuminuria.
NetworkPrioritizer: a versatile tool for network-based prioritization of candidate disease genes or other molecules
Der Childhood Trauma Screener (CTS) - Entwicklung und Validierung von Schwellenwerten zur Klassifikation
Hepatic Steatosis Is Associated With Aortic Valve Sclerosis in the General Population: The Study of Health in Pomerania (SHIP).
Individualized medicine, ethical, economical and historical perspectives
The Implications of the Incidentalome for Clinical Pharmacogenomics
Gesundheitliche Eigenverantwortung im Kontext Individualisierter Medizin.
Incidental Findings, Understanding of Risks by Research Subjects and Implications for Research Ethics,
Zufallsbefunde: Risikobewusstsein von Probandinnen und forschungsethische Konsequenzen
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
Comparison of genotyping using pooled DNA samples (allelotyping) and individual genotyping using the affymetrix genome-wide human SNP array 6.0.
Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics
Das Consentmanagement im Projekt GANI_MED - Umsetzung als Modul einer Forschungsplattform
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
The Lifetime Prevalence of Mental Disorders in North-Eastern Germany
A new, accurate predictive model for incident hypertension
Versatile prioritization of candidate disease genes or other molecules with NetworkPrioritizer
Genome-wide association study of chronic periodontitis in a general German population.
Circulating angiopoietin-2, its soluble receptor Tie-2, and mortality in the general population.
Correlates of adverse outcomes in abdominally obese individuals: findings from the five-year followup of the population-based study of health in Pomerania.
Relation of insulin-like growth factor-I and IGF binding protein 3 with markers of inflammation: results of a population-based study.
Do patients with type 1 and type 2 diabetes really have an impaired endothelial function? A population-based propensity score matching analysis.
Aldosterone and glomerular filtration - observations in the general population.
Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.
Deciphering the molecular signature of plaques, memory decline and neuron-loss using two mouse models for Alzheimer’s disease by deep sequencing
Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits.
Cohort profile: Greifswald approach to individualized medicine (GANI_MED).
Association of non-alcoholic fatty liver disease with chronic kidney disease: a systematic review and meta-analysis.
Blood cis-eQTL analysis fails to identify novel association signals among sub-threshold candidates from genome-wide association studies in restless legs syndrome.
Das GANI_MED-Metadatenmodell - Ein adaptives Modell zur Abdeckung breitgefächerter Anforderungen
Der praktische Einsatz des generischen Metadatenmodells G2D2
Bridging the gap: Improving Secondary Use of EHRs with i2b2
Daten aus der klinischen Routine – Was sind die Herausforderungen an eine Forschungsplattform?
Bridging the gap: Improving Secondary Use of EHRs with i2b2
Ethics Meets IT: Aspects and elements of Computer-based informed consent processing
The Meaning of “Individualized Medicine”: A Terminological Adjustment of a Perplexing Term
Individualized Medicine within the GANI_MED Project
Inventing Traditions, Raising Expectations. Recent Debates on “Personalized Medicine”
The “Epistemics” of “Personalized Medicine”. Rebranding Pharmacogenetics
Use of Biomarkers for the Prediction of Treatment Response: Immunoadsorption in Dilated Cardiomyopathy as a Clinical Example
The Role of Pharmacogenomics in Individualized Medicine
The Concept of Disease in the Era of Prediction
Informed Consent in GANI_MED — A sectional design for clinical epidemiological studies within Individualized Medicine
Handling incidental findings from imaging within IM related research—Results from an empirical-ethical Study
Individualized Medicine: From potential to macro innovation
Assessing Individualized Medicine — The example of immunoadsorption
How Individualized is Medicine Today? The case of heart failure in the G-DRG system
Translation of individualized medicine into clinics and the discourse of “hypothetical ethics”
Individualized medicine – ethical, economical and historical perspectives
Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.