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Originalartikel | erschienen - Druck | peer reviewed | Open Access

Salivary metabolites associated with a 5-year tooth loss identified in a population-based setting

BMC Medicine 2021 / January ; 19(1): 161 -

Bibliometric indicators

Impact Factor = 11.15

DOI = 10.1186/s12916-021-02035-z.

PubMed-ID = 34256740


Andörfer L*1, Holtfreter B1, Weiß S2, Matthes R1, Pitchika V1, Schmidt C3, Samietz S4, Kastenmüller G, Nauck M5, Völker U2, Völzke H3, Csonka L, Suhre K, Pietzner M5, Kocher T1


Background: Periodontitis is among the most common chronic diseases worldwide, and it is one of the main reasons for tooth loss. Comprehensive profiling of the metabolite content of the saliva can enable the identification of novel pathways associated with periodontitis and highlight non-invasive markers to facilitate time and cost-effective screening efforts for the presence of periodontitis and the prediction of tooth loss. Methods: We first investigated cross-sectional associations of 13 oral health variables with saliva levels of 562 metabolites, measured by untargeted mass spectrometry among a sub-sample (n = 938) of the Study of Health in Pomerania (SHIP-2) using linear regression models adjusting for common confounders. We took forward any candidate metabolite associated with at least two oral variables, to test for an association with a 5-year tooth loss over and above baseline oral health status using negative binomial regression models. Results: We identified 84 saliva metabolites that were associated with at least one oral variable cross-sectionally, for a subset of which we observed robust replication in an independent study. Out of 34 metabolites associated with more than two oral variables, baseline saliva levels of nine metabolites were positively associated with a 5-year tooth loss. Across all analyses, the metabolites 2-pyrrolidineacetic acid and butyrylputrescine were the most consistent candidate metabolites, likely reflecting oral dysbiosis. Other candidate metabolites likely reflected tissue destruction and cell proliferation. Conclusions: Untargeted metabolic profiling of saliva replicated metabolic signatures of periodontal status and revealed novel metabolites associated with periodontitis and future tooth loss. Keywords: 2-Pyrrolidineacetic acid; Butyrylputrescine; Cohort study; Metabolomics; Periodontitis; Progression; Tooth loss.

Published in

BMC Medicine

Year 2021
Month/Hj January
Impact Factor (2021) 11.15
Volume 19
Issue 1
Pages 161 -
Open Access ja
Peer reviewed ja
Article type Originalartikel
Article state erschienen - Druck
DOI 10.1186/s12916-021-02035-z.
PubMed-ID 34256740

Common journal data

Short name: BMC MED
ISSN: 1741-7015
eISSN: 1741-7015
Country: ENGLAND
Language: English

Impact factor trend

Year Impact Factor
2008 3.276
2009 3.985
2010 5.75
2011 6.035
2012 6.679
2013 7.276
2014 7.356
2015 8.005
2016 7.901
2017 9.088
2018 8.285
2019 6.782
2020 8.775
2021 11.15


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