Forschungsinformationssystem Universität Greifswald

Nolde M*, Alayash Z, Reckelkamm S, Kocher T¹, Ehmke B, Holtfreter B¹, Baurecht H, Georgakis M, Baumeister SE

1 - Zentrum für Zahn-, Mund- und Kieferheilkunde / Poliklinik für Zahnerhaltung, Parodontologie und Endodontologie

Interleukin 6 (IL-6) is considered to play a role in the dysbiotic host response in the development of periodontitis. While the inhibition of the IL-6 receptor using monoclonal antibodies is a well-established therapy for some diseases, so far, its potential benefit in patients with periodontitis has not been examined. We tested the association of genetically proxied downregulation of IL-6 signaling with periodontitis to explore whether downregulation of IL-6 signaling could represent a viable treatment target for periodontitis.