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Originalartikel | erschienen - Druck | peer reviewed

In-Vitro Biofilm Removal Efficacy Using Water Jet in Combination with Cold Plasma Technology on Dental Titanium Implants


INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023 / January ; 24(2): 1606 -


Bibliometric indicators



Citations (WOS) = 3

DOI = 10.3390/ijms24021606

PubMed-ID = 36675120


Authors

Matthes R*1, Jablonowski L1, Miebach L, Pitchika V1, Holtfreter B1, Eberhard C, Seifert L, Gerling T, Schlüter R2, Kocher T1, Bekeschus S


Abstract

Peri-implantitis-associated inflammation can lead to bone loss and implant failure. Current decontamination measures are ineffective due to the implants' complex geometry and rough surfaces providing niches for microbial biofilms. A modified water jet system (WaterJet) was combined with cold plasma technology (CAP) to achieve superior antimicrobial efficacy compared to cotton gauze treatment. Seven-day-old multi-species-contaminated titanium discs and implants were investigated as model systems. The efficacy of decontamination on implants was determined by rolling the implants over agar and determining colony-forming units supported by scanning electron microscopy image quantification of implant surface features. The inflammatory consequences of mono and combination treatments were investigated with peripheral blood mononuclear cell surface marker expression and chemokine and cytokine release profiles on titanium discs. In addition, titanium discs were assayed using fluorescence microscopy. Cotton gauze was inferior to WaterJet treatment according to all types of analysis. In combination with the antimicrobial effect of CAP, decontamination was improved accordingly. Mono and CAP-combined treatment on titanium surfaces alone did not unleash inflammation. Simultaneously, chemokine and cytokine release was dramatically reduced in samples that had benefited from additional antimicrobial effects through CAP. The combined treatment with WaterJet and CAP potently removed biofilm and disinfected rough titanium implant surfaces. At the same time, non-favorable rendering of the surface structure or its pro-inflammatory potential through CAP was not observed.

Published in

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES


Year 2023
Month/Hj January
Impact Factor (2023)
Volume 24
Issue 2
Pages 1606 -
Open Access nein
Peer reviewed ja
Article type Originalartikel
Article state erschienen - Druck
DOI 10.3390/ijms24021606
PubMed-ID 36675120

Common journal data

Short name: INT J MOL SCI
ISSN: 1661-6596
eISSN: 1422-0067
Country: SWITZERLAND
Language: English
Categories:
  • BIOCHEMISTRY & MOLECULAR BIOLOGY
  • CHEMISTRY, MULTIDISCIPLINARY


Impact factor trend

Year Impact Factor
2008 0.978
2009 1.387
2010 2.279
2011 2.598
2012 2.464
2013 2.339
2014 2.862
2015 3.257
2016 3.226
2017 3.687
2018 4.183
2019 4.556
2020 5.924
2021 6.208
2022 5.6

Key field of research at the University


Key topics


Departments

Zahnheilkunde

Projects

PERIPLAS - Periimplantitistherapie P&L

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