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Originalartikel | erschienen - EPub | peer reviewed | Open Access

Do brachycephaly and nose size predict the severity of obstructive sleep apnea (OSA)? A sample-based geometric morphometric analysis of craniofacial variation in relation to OSA syndrome and the role of confounding factors.

JOURNAL OF SLEEP RESEARCH 2023 / June ; 32(3): e13801 -

https://pubmed.ncbi.nlm.nih.gov/36579627[PubMed] https://onlinelibrary.wiley.com/doi/full/10.1111/jsr.13801

Bibliometric indicators

Citations (WOS) = 0

DOI = 10.1111/jsr.13801

PubMed-ID = 36579627


Daboul A*1, Krüger M1, Ivanonvka T, Obst A1, Ewert R2, Stubbe B2, Fietze I, Penzel T, Hosten N3, Biffar R1, Cardini A


Obstructive sleep apnea is a common disorder that leads to sleep fragmentation and is potentially bidirectionally related to a variety of comorbidities, including an increased risk of heart failure and stroke. It is often considered a consequence of anatomical abnormalities, especially in the head and neck, but its pathophysiology is likely to be multifactorial in origin. With geometric morphometrics, and a large sample of adults from the Study for Health in Pomerania, we explore the association of craniofacial morphology to the apnea-hypopnea index used as an estimate of obstructive sleep apnea severity. We show that craniofacial size and asymmetry, an aspect of morphological variation seldom analysed in obstructive sleep apnea research, are both uncorrelated to apnea-hypopnea index. In contrast, as in previous analyses, we find evidence that brachycephaly and larger nasal proportions might be associated to obstructive sleep apnea severity. However, this correlational signal is weak and completely disappears when age-related shape variation is statistically controlled for. Our findings suggest that previous work might need to be re-evaluated, and urge researchers to take into account the role of confounders to avoid potentially spurious findings in association studies.

Published in


Year 2023
Month/Hj June
Impact Factor (2023)
Volume 32
Issue 3
Pages e13801 -
Open Access ja
Peer reviewed ja
Article type Originalartikel
Article state erschienen - EPub
DOI 10.1111/jsr.13801
PubMed-ID 36579627

Common journal data

Short name: J SLEEP RES
ISSN: 0962-1105
eISSN: 1365-2869
Country: ENGLAND
Language: English

Impact factor trend

Year Impact Factor
2008 3.255
2009 3.5
2010 3.361
2011 3.157
2012 3.043
2013 2.949
2014 3.347
2015 3.093
2016 3.259
2017 3.433
2018 3.432
2019 3.623
2020 3.981
2021 5.296

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