Originalartikel | erschienen - Druck | peer reviewed | Open Access
Effect of periodontal treatment on preclinical Alzheimer's disease-Results of a trial emulation approach
Alzheimers & Dementia
2022 / January
;
18(1):
127 - 141
https://pubmed.ncbi.nlm.nih.gov/34050719[PubMed]
Authors
Schwahn C*1, Frenzel S2, Holtfreter B3, van der Auwera-Palitschka S2,4, Pink C5, Bülow R6, Friedrich N7, Völzke H8, Biffar R1, Alzheimer's D, Kocher T3, Grabe H2,4
Affiliations
1 - Zentrum für Zahn-, Mund- und Kieferheilkunde / Poliklinik für Zahnärztliche Prothetik, Alterszahnheilkunde und Medizinische Werkstoffkunde
2 - Klinik und Poliklinik für Psychiatrie und Psychotherapie
3 - Zentrum für Zahn-, Mund- und Kieferheilkunde / Poliklinik für Zahnerhaltung,Parodontologie, Endodontologie; Präventive Zahnmedizin und Kinderzahnheilkunde
4 - Deutsches Zentrum für Neurodegenerative Erkrankungen Rostock / Greifswald Teilstandort Greifswald
5 - Zentrum für Zahn-, Mund- und Kieferheilkunde / Poliklinik für Kieferorthopädie
6 - Zentrum für Radiologie / Institut für Diagnostische Radiologie und Neuroradiologie
7 - Institut für Klinische Chemie und Laboratoriumsmedizin
8 - Institut für Community Medicine / Abt. SHIP KEF
Abstract
Introduction: We investigated the relationship between periodontal treatment and pre-clinical Alzheimer's disease (AD).
Methods: In this quasi-experimental design, 177 periodontally treated patients from the "Greifswald Approach to Individualized Medicine" cohort, which used the same protocols as the population-based Study of Health in Pomerania TREND (SHIP-TREND), and 409 untreated subjects from SHIP-TREND were analyzed. Subjects were younger than 60 years at the magnetic resonance imaging examination, with a median observation period of 7.3 years. Imaging markers for brain atrophy in late-onset AD and brain aging were used as the outcomes.
Results: Robust to sensitivity analyses, periodontal treatment had a favorable effect on AD-related brain atrophy (-0.41; 95% confidence interval: -0.70 to -0.12; P = .0051), which corresponds to a shift from the 50th to the 37th percentile of the outcome distribution. For brain aging, the treatment effect was uncertain.
Conclusion: Periodontitis is related to pre-clinical AD in our population.
Published in
Alzheimers & Dementia
Year | 2022 |
Month/Hj | January |
Impact Factor (2022) | |
Volume | 18 |
Issue | 1 |
Pages | 127 - 141 |
Open Access | ja |
Peer reviewed | ja |
Article type | Originalartikel |
Article state | erschienen - Druck |
DOI | 10.1002/alz.12378. |
PubMed-ID | 34050719 |
Common journal data
Short name: ALZHEIMERS DEMENT
ISSN: 1552-5260
eISSN: 1552-5279
Country: USA
Language: English
Categories:
Impact factor trend
ISSN: 1552-5260
eISSN: 1552-5279
Country: USA
Language: English
Categories:
- CLINICAL NEUROLOGY
Impact factor trend
Year | Impact Factor |
---|---|
2009 | 4.553 |
2010 | 5.902 |
2011 | 6.373 |
2012 | 14.483 |
2013 | 17.472 |
2014 | 12.407 |
2015 | 11.619 |
2016 | 9.478 |
2017 | 12.74 |
2018 | 14.423 |
2019 | 17.127 |
2020 | 21.566 |
2021 | 16.655 |
Departments
Community Medicine
Neurologische/psychische Erkrankungen
Neurologische/psychische Erkrankungen
Projects
GANI_MED Teilprojekt PB2 2: Kohorte 2 - Zerebrovaskuläre Erkrankungen und Parodontalerkrankungen