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Originalartikel | erschienen - Druck | peer reviewed | Open Access

Periodontitis Is Related to Exercise Capacity: Two Cross-sectional Studies.

JOURNAL OF DENTAL RESEARCH 2021 ; 100(8): 824 - 832


Bibliometric indicators

Impact Factor = 8.924

Citations (WOS) = 4

DOI = 10.1177/0022034521995428

PubMed-ID = 33655783


Although a potential link between periodontitis and cardiorespiratory fitness might provide a reasonable explanation for effects of tooth-related alterations seen on cardiometabolic diseases, evidence is currently limited. Thus, we investigated the association between clinically assessed periodontitis and cardiopulmonary exercise testing (CPET). Data from 2 independent cross-sectional population-based studies (5-y follow-up of the Study of Health in Pomerania [SHIP-1;  = 1,639] and SHIP-Trend-0 [ = 2,439]) were analyzed. Participants received a half-mouth periodontal examination, and teeth were counted. CPET was based on symptom limited-exercise tests on a bicycle ergometer. Associations of periodontitis parameters with CPET parameters were analyzed by confounder-adjusted multivariable linear regression. In the total sample, mean pocket probing depth (PPD), mean clinical attachment levels, and number of teeth were consistently associated with peak oxygen uptake (peakVO) and exercise duration in both studies, even after restriction to cardiorespiratory healthy participants. Statistically significant associations with oxygen uptake at anaerobic threshold (VO@AT), slope of the efficiency of ventilation in removing carbon dioxide, and peak oxygen pulse (VÉ/VCO slope) occurred. Further, interactions with age were identified, such that mainly older individuals with higher levels of periodontal disease severity were associated with lower peakVO. Restricted to never smokers, associations with mean clinical attachment levels and the number of teeth mostly diminished, while associations of mean PPD with peakVO, VO@AT, VÉ/VCO slope, and exercise duration in SHIP-1 and SHIP-Trend-0 were confirmed. In SHIP-1, mean peakVO was 1,895 mL/min in participants with a mean PPD of 1.6 mm and 1,809 mL/min in participants with a mean PPD of 3.7 mm. To conclude, only mean PPD reflecting current disease severity was consistently linked to cardiorespiratory fitness in 2 cross-sectional samples of the general population. If confirmed in well-designed large-scale longitudinal studies, the association between periodontitis and cardiorespiratory fitness might provide a biologically plausible mechanism linking periodontitis with cardiometabolic diseases.

Published in


Year 2021
Impact Factor (2021) 8.924
Volume 100
Issue 8
Pages 824 - 832
Open Access ja
Peer reviewed ja
Article type Originalartikel
Article state erschienen - Druck
DOI 10.1177/0022034521995428
PubMed-ID 33655783

Common journal data

Short name: J DENT RES
ISSN: 0022-0345
eISSN: 1544-0591
Country: USA
Language: English

Impact factor trend

Year Impact Factor
2008 3.142
2009 3.458
2010 3.773
2011 3.486
2012 3.826
2013 4.144
2014 4.139
2015 4.602
2016 4.755
2017 5.38
2018 5.125
2019 4.914
2020 6.116
2021 8.924


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