Forschungsinformationssystem Universität Greifswald

Gebauer A*¹, Schmidt-Schuchert S², Hoffmann W¹

1 - Institut für Community Medicine / Abt. Versorgungsepidemiologie und Community Health

2 - Institut für Psychologie / AG Gesundheit und Prävention

Lab-on-a-chip systems (LOCs) are a useful aid for the individualization of therapeutic algorithms at the point-of-care. We performed a systematic literature review on LOCs for diseases with a global impact for health care. 1,007 articles matched the previously specified search criteria, thereof 65 studies could be included in this review. 55 different LOCs were evaluated, most for diagnosis or monitoring of cancer (n=24). For other diseases we found considerably less analysed LOCs. The analytical performance of the LOCs was usually very good, 37 (67%) LOCs had a sensitivity higher than 90%. Although lab-on-a-chip systems performance has been positively evaluated in the great majority of studies, the testing was mostly limited to the research lab setting rather than real-world scenarios.