Original article | published - printed
Daptomycin versus Friulimicin B: in-depth profiling of Bacillus subtilis cell envelope stress responses
Antimicrob Agents Chemother
2009 ;
53(4):
1619 - 1623
Authors
Affiliations
Abstract
The related lipo(depsi)peptide antibiotics daptomycin and friulimicin B show great potential in the treatment of multiply resistant gram-positive pathogens. Applying genome-wide in-depth expression profiling, we compared the respective stress responses of Bacillus subtilis. Both antibiotics target envelope integrity, based on the strong induction of extracytoplasmic function sigma factor-dependent gene expression. The cell envelope stress-sensing two-component system LiaRS is exclusively and strongly induced by daptomycin, indicative of different mechanisms of action in the two compounds.
Further details
Antimicrobial agents and chemotherapy;Wecke, Tina
Zuhlke, Daniela
Mader, Ulrike
Jordan, Sina
Voigt, Birgit
Pelzer, Stefan
Labischinski, Harald
Homuth, Georg
Hecker, Michael
Mascher, Thorsten
Comparative Study
Research Support, Non-U.S. Gov't
United States
Antimicrob Agents Chemother. 2009 Apr;53(4):1619-23. doi: 10.1128/AAC.01046-08. Epub 2009 Jan 21.
Published in
Antimicrob Agents Chemother
| Year | 2009 |
| Impact Factor (2009) | |
| Volume | 53 |
| Issue | 4 |
| Pages | 1619 - 1623 |
| Open Access | nein |
| Peer reviewed | nein |
| Article type | Original article |
| Article state | published - printed |
| DOI | 10.1128/aac.01046-08 |
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