Forschungsinformationssystem Universität Greifswald

Lorbeer R*, Dörr M, Ittermann T, Koch B, Ewert R, Rettig R, Nauck M, Felix S, Wallaschofski H, Völzke H

Zentrum für Innere Medizin / Klinik für Innere Medizin B

Institut für Physiologie

Institut für Klinische Chemie und Laboratoriumsmedizin

Institut für Community Medicine / Abt. SHIP KEF

Background: Studies on the relation between thyroid function and exercise blood pressure (EBP) are rare and not population-based, and have yielded inconsistent results. The aim of this study was to investigate whether serum thyrotropin (TSH) levels are related to increased EBP. Methods: Cross-sectional data from 1438 subjects (711 women) aged 25-83 years without histories of cardiovascular diseases from the 5-year follow-up of the population-based Study of Health in Pomerania (SHIP-1) were analyzed. Blood pressure was measured at the 100?W stage of a symptom-limited bicycle ergometry test. Increased EBP was defined as a value above the sex- and age-specific 80th percentile of participants with serum TSH levels within the reference range (0.25-2.12?mIU/L). Results: There was no association between serum TSH levels and EBP after adjusting for sex, age, waist circumference, diabetes mellitus, smoking status, and antihypertensive medication. The odds for increased systolic EBP (odds ratio 1.24, 95% confidence interval 0.88; 1.76) and diastolic EBP (odds ratios 0.98, 95% confidence interval 0.70; 1.39) as well as for exercise-induced increase of systolic and diastolic blood pressure were not significantly different between subjects with high and low serum TSH levels within the reference range. Similar findings were found for both subjects with TSH levels below and above the reference range, respectively. Conclusions: We conclude that serum TSH levels are not associated with exercise-related blood pressure response.