Original article | published - printed | peer reviewed
In-Vitro Biofilm Removal Efficacy Using Water Jet in Combination with Cold Plasma Technology on Dental Titanium Implants
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2023 / January
;
24(2):
1606 -
Authors
Matthes R*1, Jablonowski L1, Miebach L, Pitchika V1, Holtfreter B1, Eberhard C, Seifert L, Gerling T, Schlüter R2, Kocher T1, Bekeschus S
Affiliations
Abstract
Peri-implantitis-associated inflammation can lead to bone loss and implant failure. Current decontamination measures are ineffective due to the implants' complex geometry and rough surfaces providing niches for microbial biofilms. A modified water jet system (WaterJet) was combined with cold plasma technology (CAP) to achieve superior antimicrobial efficacy compared to cotton gauze treatment. Seven-day-old multi-species-contaminated titanium discs and implants were investigated as model systems. The efficacy of decontamination on implants was determined by rolling the implants over agar and determining colony-forming units supported by scanning electron microscopy image quantification of implant surface features. The inflammatory consequences of mono and combination treatments were investigated with peripheral blood mononuclear cell surface marker expression and chemokine and cytokine release profiles on titanium discs. In addition, titanium discs were assayed using fluorescence microscopy. Cotton gauze was inferior to WaterJet treatment according to all types of analysis. In combination with the antimicrobial effect of CAP, decontamination was improved accordingly. Mono and CAP-combined treatment on titanium surfaces alone did not unleash inflammation. Simultaneously, chemokine and cytokine release was dramatically reduced in samples that had benefited from additional antimicrobial effects through CAP. The combined treatment with WaterJet and CAP potently removed biofilm and disinfected rough titanium implant surfaces. At the same time, non-favorable rendering of the surface structure or its pro-inflammatory potential through CAP was not observed.
Published in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year | 2023 |
Month/Hj | January |
Impact Factor (2023) | 4.9 |
Volume | 24 |
Issue | 2 |
Pages | 1606 - |
Open Access | nein |
Peer reviewed | ja |
Article type | Original article |
Article state | published - printed |
DOI | 10.3390/ijms24021606 |
PubMed-ID | 36675120 |
Common journal data
Short name: INT J MOL SCI
ISSN: 1661-6596
eISSN: 1422-0067
Country: SWITZERLAND
Language: English
Categories:
Impact factor trend
ISSN: 1661-6596
eISSN: 1422-0067
Country: SWITZERLAND
Language: English
Categories:
- BIOCHEMISTRY & MOLECULAR BIOLOGY
- CHEMISTRY, MULTIDISCIPLINARY
Impact factor trend
Year | Impact Factor |
---|---|
2008 | 0.978 |
2009 | 1.387 |
2010 | 2.279 |
2011 | 2.598 |
2012 | 2.464 |
2013 | 2.339 |
2014 | 2.862 |
2015 | 3.257 |
2016 | 3.226 |
2017 | 3.687 |
2018 | 4.183 |
2019 | 4.556 |
2020 | 5.924 |
2021 | 6.208 |
2022 | 5.6 |
2023 | 4.9 |
Key field of research at the University
Key topics
Departments
Zahnheilkunde
Projects
PERIPLAS - Periimplantitistherapie P&L