Forschungsinformationssystem Universität Greifswald

Wecke T*, Zuhlke D, Mader U, Jordan S, Voigt B, Pelzer S, Labischinski H, Homuth G, Hecker M, Mascher T

The related lipo(depsi)peptide antibiotics daptomycin and friulimicin B show great potential in the treatment of multiply resistant gram-positive pathogens. Applying genome-wide in-depth expression profiling, we compared the respective stress responses of Bacillus subtilis. Both antibiotics target envelope integrity, based on the strong induction of extracytoplasmic function sigma factor-dependent gene expression. The cell envelope stress-sensing two-component system LiaRS is exclusively and strongly induced by daptomycin, indicative of different mechanisms of action in the two compounds.

Antimicrobial agents and chemotherapy;Wecke, Tina Zuhlke, Daniela Mader, Ulrike Jordan, Sina Voigt, Birgit Pelzer, Stefan Labischinski, Harald Homuth, Georg Hecker, Michael Mascher, Thorsten Comparative Study Research Support, Non-U.S. Gov't United States Antimicrob Agents Chemother. 2009 Apr;53(4):1619-23. doi: 10.1128/AAC.01046-08. Epub 2009 Jan 21.